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Causation Reports

Methotrexate Letter Report


The drug is known to cause bone marrow suppression, including thrombocytopenia and leukopenia, resulting in an increased risk of infection, including sepsis.1  Methotrexate is known to result in elevated liver enzyme activity and hepatotoxicity and gastrointestinal problems, including rectal bleeding.  Aphasia with mood alterations and cognitive dysfunction are also characteristic of methotrexate overdose.  Finally, an overdose of methotrexate is known to be life threatening, increasing the risk of death. One case reported a patient dying 22 days after overdose.

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